Breast reduction is a surgical intervention that allows the reduction of breast volume by excising a part of the breasts containing fat, mammary gland, and skin tissue. After the removal of excess tissues, the breasts are reconstructed and repositioned to an anatomically and aesthetically correct position on the chest wall. The procedure is in high demand nowadays as women confronted with overly large breasts can find it difficult to do even simple physical activities such as running. Moreover, the breasts are an important feature of the woman’s body that can influence the self-esteem and the body image of the patient. The main reasons why women choose to undergo the breast reduction surgery are: – Breasts that are overly large and not aesthetically pleasant – Breasts that cause back, neck and shoulder pain due to their large volume – Breasts that cause difficulties in breathing, especially when undergoing physically demanding activities – Difficulty or impossibility to perform regular physical activities or sports – Asymmetries when one breast is much bigger than the other. Having overly large breasts can also cause emotional discomfort and struggle for women who don’t want to be defined by the size of their bust. Undergoing the breast reduction procedure will alleviate the discomforts associated with having huge breasts and will also improve the overall appearance of the patient. The procedure is a complex surgical operation that should be performed only in an accredited medical facility by a board-certified plastic surgeon. Breast reduction is often performed with the patient under general anesthesia. General anesthesia is a sort of medication-induced coma. When under the effects of general anesthesia, the patient loses protection reflexes. A variety of medication can be administered with the aim of inducing sleep, amnesia, lack of pain, relaxation of the muscles and the loss of control and autonomous reflexes. The optimal combination of these agents is decided for each patient after a consultation with the anesthesiologist. Also, the doctor should consider the medical history of the patient before deciding on the right type of anesthesia. General anesthesia has been used for decades as it allows the patient to be comfortable during lengthy procedures and have no memories of what happens during the operation. This means that the pain or discomfort that occurred during the surgery won’t be felt or remembered. General anesthesia uses intravenous and inhalation agents to allow for a proper surgical access at the surgical spot. When using general anesthesia, the purpose is for the patient to lose the natural response to pain, to lose memory, consciousness and motor reflexes, as well as relaxation of the muscles. General anesthesia is often recommended for procedures that will last over an hour for the comfort of the patient. Of course, it is important for the patient to have a consultation with the anesthetist to rule out any potential contraindications to general anesthesia.